Table 3

Number of genes showing changes in early dynamic expression after PMA treatment with promoter regions that are bound by EGR-1

Number of promoters bound at time points after PMA treatment


1 hour

2 hours

4 hours

6 hours


Up-regulated

5 (23.8%)

7 (25.0%)

9 (14.3%)

3 (12.5%)

Down-regulated

0 (0%)

0 (0%)

4 (13.8%)

4 (12.9%)


After PMA treatment, 136 genes were up-regulated and 61 down-regulated. Of these, 24 and 8, respectively, were found to be EGR-1 target genes. Percentage values indicate the number of target genes with bound promoters whose expression was up- or down-regulated at the indicated time point out of all EGR-1 target genes up- or down-regulated, respectively, over the entire time course (0-6 hours).

Kubosaki et al. Genome Biology 2009 10:R41   doi:10.1186/gb-2009-10-4-r41

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