Table 7

Enriched human pathways for susceptibility to breast cancer

KEGG pathway ID

Pathway description

SEPEA_NT3

SEPEA_NT3*


[path:hsa04370]

VEGF signaling pathway

1.69E-04

5.14E-04

[path:hsa04662]

B-cell receptor signaling

3.32E-04

3.51E-04

[path:hsa04630]

Jak-STAT signaling

8.91E-04

0.0417

[path:hsa04520]

Adherens junction

0.0014

0.1438

[path:hsa04810]

Regulation of actin cytoskeleton

0.0027

0.0717

[path:hsa04150]

mTOR signaling

0.0047

0.0052

[path:hsa04664]

Fc epsilon RI signaling

0.0081

5.99E-04

[path:hsa04510]

Focal adhesion

0.0103

0.0648

[path:hsa04012]

ErbB signaling

0.0103

8.51E-04

[path:hsa04210]

Apoptosis

0.0108

7.97E-04

[path:hsa03440]

Homologous recombination

0.0147

0.0016

[path:hsa04660]

T cell receptor signaling

0.0182

0.001

[path:hsa04010]

MAPK signaling

0.0183

0.0183

[path:hsa04910]

Insulin signaling

0.0191

0.0032

[path:hsa04514]

Cell adhesion molecules

0.0274

0.2407

[path:hsa04115]

P53 signaling

0.0306

0.0093

[path:hsa04620]

Toll-like receptor signaling pathway

0.0391

0.0193


Enriched KEGG [44] pathways (with P-value ≤ 0.05) obtained using genes from the OMIM database [49] that confer susceptibility to breast cancer. P-values were obtained using the SEPEA_NT3 and SEPEA_NT3* analysis.

Thomas et al. Genome Biology 2009 10:R44   doi:10.1186/gb-2009-10-4-r44

Open Data