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MotifAdjuster: a tool for computational reassessment of transcription factor binding site annotations

Jens Keilwagen1*, Jan Baumbach2, Thomas A Kohl34 and Ivo Grosse15

Author Affiliations

1 Leibniz Institute of Plant Genetics and Crop Plant Research Gatersleben (IPK), Corrensstraße 3, 06466 Gatersleben, Germany

2 International Computer Science Institute, 1947 Center Street, Berkeley, California 94704, USA

3 International NRW Graduate School in Bioinformatics and Genome Research, Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 27, 33615 Bielefeld, Germany

4 Institute for Genome Research and Systems Biology (IGS), Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 27, 33615 Bielefeld, Germany

5 Institute of Computer Science, Martin Luther University Halle-Wittenberg, Von-Seckendorff-Platz 1, 06120 Halle, Germany

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Genome Biology 2009, 10:R46  doi:10.1186/gb-2009-10-5-r46

Published: 1 May 2009

Abstract

Valuable binding-site annotation data are stored in databases. However, several types of errors can, and do, occur in the process of manually incorporating annotation data from the scientific literature into these databases. Here, we introduce MotifAdjuster http://dig.ipk-gatersleben.de/MotifAdjuster.html webcite, a tool that helps to detect these errors, and we demonstrate its efficacy on public data sets.