MotifAdjuster: a tool for computational reassessment of transcription factor binding site annotations

doi:10.1186/gb-2009-10-5-r46

Genome Biology

Volume 10
Issue 5

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Keilwagen J
Baumbach J
Kohl TA
Grosse I

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Kohl TA
Grosse I
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MotifAdjuster: a tool for computational reassessment of transcription factor binding site annotations

Jens Keilwagen¹ , Jan Baumbach² , Thomas A Kohl³^,4 and Ivo Grosse¹^,5

¹Leibniz Institute of Plant Genetics and Crop Plant Research Gatersleben (IPK), Corrensstraße 3, 06466 Gatersleben, Germany

²International Computer Science Institute, 1947 Center Street, Berkeley, California 94704, USA

³International NRW Graduate School in Bioinformatics and Genome Research, Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 27, 33615 Bielefeld, Germany

⁴Institute for Genome Research and Systems Biology (IGS), Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 27, 33615 Bielefeld, Germany

⁵Institute of Computer Science, Martin Luther University Halle-Wittenberg, Von-Seckendorff-Platz 1, 06120 Halle, Germany

author email corresponding author email

Genome Biology 2009, 10:R46doi:10.1186/gb-2009-10-5-r46


Published:	1 May 2009

Subject areas: Bioinformatics, Molecular biology

Abstract

Valuable binding-site annotation data are stored in databases. However, several types of errors can, and do, occur in the process of manually incorporating annotation data from the scientific literature into these databases. Here, we introduce MotifAdjuster http://dig.ipk-gatersleben.de/MotifAdjuster.html webcite, a tool that helps to detect these errors, and we demonstrate its efficacy on public data sets.