Table 4

Subsets of GO terms (biological process, molecular function and cellular component) over-represented for co-regulated transcripts encoding highly disordered proteins

Term

Description

Disorder (60,80]%

Disorder (80,100]%

[GO:0005769]

Early endosome

Down

Down

[GO:0005770]

Late endosome

Down

Down

[GO:0005838]

Proteasome regulatory particle

Down

Down

[GO:0016272]

Prefoldin complex

Down

[GO:0031371]

Ubiquitin conjugating enzyme complex

Down

[GO:0000145]

Exocyst

Down

[GO:0000502]

Proteasome complex

Down

[GO:0032991]

Macromolecular complex

Up

[GO:0043234]

Protein complex

Up

[GO:0019872]

Small conjugating protein ligase activity

Up

[GO:0042803]

Protein homodimerization activity

Up

[GO:0051131]

Chaperone-mediated protein complex assembly

Up

[GO:0008639]

Small protein conjugating enzyme activity

Up

[GO:0004842]

Ubiquitin-protein ligase activity

Up

[GO:0016874]

Ligase activity

Up

[GO:0006512]

Ubiquitin cycle

Up

[GO:0004869]

Cysteine protease inhibitor activity

Up

Up

[GO:0004866]

Endopeptidase inhibitor activity

Up

Up

[GO:0030414]

Protease inhibitor activity

Up

Up

[GO:0051082]

Unfolded protein binding

Up

Up

[GO:0046983]

Protein dimerization activity

Up

Up

[GO:0051291]

Protein hetero-oligomerization

Up

[GO:0007032]

Endosome organization and biogenesis

Up

[GO:0006983]

ER overload response

Up

[GO:0051087]

Chaperone binding

Up

[GO:0031579]

Lipid raft organization and biogenesis

Up

[GO:0016235]

Aggresome

Up

[GO:0016234]

Inclusion body

Up

[GO:0016926]

Protein desumoylation

Up

[GO:0008581]

Ubiquitin specific protease 5 activity

Up

[GO:0006622]

Protein targeting to lysosome

Up

[GO:0019783]

Small conjugating protein-specific protease activity

Down

[GO:0008219]

Cell death

Down

[GO:0007049]

Cell death

Down

[GO:0051603]

Proteolysis involved in cellular protein catabolic process

Down

Down

[GO:0004221]

Ubiquitin thiolesterase activity

Down

Down

[GO:0016197]

Endosome transport

Down

Down

[GO:0016874]

Ligase activity

Down

Down

[GO:0004843]

Ubiquitin-specific protease activity

Down

Down

[GO:0051082]

Unfolded protein binding

Down

Down

[GO:0000209]

Protein polyubiquitination

Down

Down

[GO:0006511]

Ubiquitin-dependent protein catabolic process

Down

[GO:0006512]

Ubiquitin cycle

Down

[GO:0051087]

Chaperone binding

Down

[GO:0030968]

Unfolded protein response

Down

[GO:0030100]

Regulation of endocytosis

Down

[GO:0043488]

Regulation of mRNA stability

Down

[GO:0031396]

Regulation of protein ubiquitination

Down

Up, up-regulation; down, down-regulation.

Edwards et al. Genome Biology 2009 10:R50   doi:10.1186/gb-2009-10-5-r50