Adipose-hypothalamus network partitioning and analysis. (a) Network highlight based on chromosomal location and cis expression quantitative trait loci (eQTL) status. Each node is colored according to chromosomal location with different colors for different chromosomes. Large nodes correspond to genes that have cis-eQTL. Two types of subnetworks are observed in the network: type 1 subnetworks that contain genes located on the same chromosome that also have cis-eQTLs; and type 2 subnetworks with genes that are neither located on the same chromosome nor have cis-eQTLs. (b) Highlighted are all the type 2 subnetworks, as identified by the partitioning algorithm. (c) P-value heatmap for the association between clinical traits and gene expression traits for the type 2 subnetworks. The heatmap scale ranges from 1 (green) to 10-10 (red). All P-values smaller than 10-10 are set to 10-10. For a detailed description of clinical traits see Materials and methods. (d) Gene Ontology enrichments for type 2 subnetworks of size greater than 10. To validate the robustness of the overlap, we recorded the number of GO biological process (GOBP) terms when the FDR corrected P-values resulting from the Fischer's exact test, -log10(P-value), exceeded 2 and 3. The 'Top GOBP' column lists the GOBP terms that have the lowest Fischer's exact test P-value.
Dobrin et al. Genome Biology 2009 10:R55 doi:10.1186/gb-2009-10-5-r55