Adipose-hypothalamus network backbone. We define the network backbone as the bonds most visited by the all-pair shortest paths algorithm on the TTC network. In order to generate a robust backbone, we assigned P-values of Spearman correlations as bond weights. The subnetworks selected for further analysis are represented by a small number of representative genes on the backbone. Perturbing these genes most likely triggers responses in the complementary tissue.
Dobrin et al. Genome Biology 2009 10:R55 doi:10.1186/gb-2009-10-5-r55