Genome-wide association obesity gene Aif1 in TTC networks. Detailed view of TTC network connections for Aif1 identified in genome-wide association studies as associated with obesity. Nodes are colored based on the tissue of origin for the mRNA profile, such that white, blue and red are gene expressions in adipose, liver and hypothalamus, respectively. Rectangle nodes denote genome-wide association candidate genes for obesity. (a) Liver Aif1 and its connection to hypothalamus and adipose tissue. (b Adipose Aif1 and its connections to liver. (c) Hypothalamus Aif1 and its connections to liver and adipose.
Dobrin et al. Genome Biology 2009 10:R55 doi:10.1186/gb-2009-10-5-r55