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The Cell Cycle Ontology: an application ontology for the representation and integrated analysis of the cell cycle process

Erick Antezana12, Mikel Egaña3, Ward Blondé4, Aitzol Illarramendi5, Iñaki Bilbao5, Bernard De Baets4, Robert Stevens3, Vladimir Mironov6 and Martin Kuiper6*

Author Affiliations

1 Department of Plant Systems Biology, VIB, Technologiepark 927, B-9052 Gent, Belgium

2 Department of Molecular Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium

3 School of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UK

4 Department of Applied Mathematics, Biometrics and Computer Science, Ghent University, Coupure links 653, B-9000 Gent, Belgium

5 Noray Bioinformatics, SL Parque Tecnológico 801 A, 2°, 48160 Derio (Bizkaia), Spain

6 Department of Biology, Norwegian University of Science and Technology, Høgskoleringen 5, NO-7491 Trondheim, Norway

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Genome Biology 2009, 10:R58  doi:10.1186/gb-2009-10-5-r58

Published: 29 May 2009

Abstract

The Cell Cycle Ontology (http://www.CellCycleOntology.org) webcite is an application ontology that automatically captures and integrates detailed knowledge on the cell cycle process. Cell Cycle Ontology is enabled by semantic web technologies, and is accessible via the web for browsing, visualizing, advanced querying, and computational reasoning. Cell Cycle Ontology facilitates a detailed analysis of cell cycle-related molecular network components. Through querying and automated reasoning, it may provide new hypotheses to help steer a systems biology approach to biological network building.