Sequence patches on MAPK surfaces define protein-protein interactions
1 Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7365, USA
2 Joint Department of Biomedical Engineering, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7365, USA
Genome Biology 2009, 10:222 doi:10.1186/gb-2009-10-6-222Published: 5 June 2009
Recent studies on the modularity of mitogen-activated protein kinases show how redesigning 'surface patches' on a protein can change the topology of a signaling network.