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Sequence patches on MAPK surfaces define protein-protein interactions

Gary L Johnson1* and Shawn M Gomez2

Author Affiliations

1 Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7365, USA

2 Joint Department of Biomedical Engineering, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7365, USA

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Genome Biology 2009, 10:222  doi:10.1186/gb-2009-10-6-222

Published: 5 June 2009

Abstract

Recent studies on the modularity of mitogen-activated protein kinases show how redesigning 'surface patches' on a protein can change the topology of a signaling network.