DNA breaks as triggers for antigenic variation in African trypanosomes
London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Genome Biology 2009, 10:223 doi:10.1186/gb-2009-10-6-223Published: 8 June 2009
The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.