Genome Biology
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MinireviewDNA breaks as triggers for antigenic variation in African trypanosomesSam Alsford, David Horn and Lucy Glover London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK author email corresponding author email
Genome Biology 2009,
10:223doi:10.1186/gb-2009-10-6-223
Subject areas: Genetics, Genome studies, Immunology, Microbiology and parasitology, Molecular biology Abstract
The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat. |