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Open Access Highly Accessed Research

Metabolic-network-driven analysis of bacterial ecological strategies

Shiri Freilich12*, Anat Kreimer3, Elhanan Borenstein45, Nir Yosef1, Roded Sharan1, Uri Gophna6 and Eytan Ruppin12*

Author affiliations

1 The Blavatnik School of Computer Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel

2 School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel

3 School of Mathematical Science, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel

4 Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA

5 Santa Fe Institute, Santa Fe, NM 87501, USA

6 Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel

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Citation and License

Genome Biology 2009, 10:R61  doi:10.1186/gb-2009-10-6-r61

Published: 5 June 2009

Abstract

Background

The growth-rate of an organism is an important phenotypic trait, directly affecting its ability to survive in a given environment. Here we present the first large scale computational study of the association between ecological strategies and growth rate across 113 bacterial species, occupying a variety of metabolic habitats. Genomic data are used to reconstruct the species' metabolic networks and habitable metabolic environments. These reconstructions are then used to investigate the typical ecological strategies taken by organisms in terms of two basic species-specific measures: metabolic variability - the ability of a species to survive in a variety of different environments; and co-habitation score vector - the distribution of other species that co-inhabit each environment.

Results

We find that growth rate is significantly correlated with metabolic variability and the level of co-habitation (that is, competition) encountered by an organism. Most bacterial organisms adopt one of two main ecological strategies: a specialized niche with little co-habitation, associated with a typically slow rate of growth; or ecological diversity with intense co-habitation, associated with a typically fast rate of growth.

Conclusions

The pattern observed suggests a universal principle where metabolic flexibility is associated with a need to grow fast, possibly in the face of competition. This new ability to produce a quantitative description of the growth rate-metabolism-community relationship lays a computational foundation for the study of a variety of aspects of the communal metabolic life.