Research
The conservation and evolutionary modularity of metabolism
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* Corresponding authors: José M Peregrín-Alvarez peregrin@sickkids.ca - John Parkinson jparkin@sickkids.ca
1 Program in Molecular Structure and Function, Hospital for Sick Children, College Street, Toronto, ON, M5G 1L7, Canada
2 Department of Molecular Biology and Biochemistry, University of Malaga, Avda. Cevantes, 29071 Malaga, Spain
3 Department of Molecular Genetics, University of Toronto, King's College Circle, Toronto, ON, M5S 1A8, Canada
4 Department of Biochemistry, University of Toronto, Toronto, Kings' College Circle, ON, M5S 1A8, Canada
Genome Biology 2009, 10:R63 doi:10.1186/gb-2009-10-6-r63
Published: 12 June 2009Additional files
Additional data file 1:
Supplemental results, discussion, methods and Figures S1-S7.
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Additional data file 2:
The complete and partial genomes used in this study.
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Additional data file 3:
Conservation of individual enzymes.
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Additional data file 4:
Enzymes restricted to either bacteria or eukaryotes.
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Additional data file 5:
Conservation of 118 metabolic pathways analyzed in this study.
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Additional data file 6:
Modularity of 166 metabolic pathways analyzed in this study.
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Additional data file 7:
Conservation of 25 regulatory pathways defined by KEGG.
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