The conservation and evolutionary modularity of metabolism

doi:10.1186/gb-2009-10-6-r63

Genome Biology

Volume 10
Issue 6

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The conservation and evolutionary modularity of metabolism

José M Peregrín-Alvarez¹^,2 , Chris Sanford¹^,3 and John Parkinson¹^,3^,4

¹Program in Molecular Structure and Function, Hospital for Sick Children, College Street, Toronto, ON, M5G 1L7, Canada

²Department of Molecular Biology and Biochemistry, University of Malaga, Avda. Cevantes, 29071 Malaga, Spain

³Department of Molecular Genetics, University of Toronto, King's College Circle, Toronto, ON, M5S 1A8, Canada

⁴Department of Biochemistry, University of Toronto, Toronto, Kings' College Circle, ON, M5S 1A8, Canada

author email corresponding author email

Genome Biology 2009, 10:R63doi:10.1186/gb-2009-10-6-r63


Published:	12 June 2009

Subject areas: Evolution, Genome studies

Additional files

Additional data file 1:

Supplemental results, discussion, methods and Figures S1-S7.

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Additional data file 2:

The complete and partial genomes used in this study.

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Additional data file 3:

Conservation of individual enzymes.

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Additional data file 4:

Enzymes restricted to either bacteria or eukaryotes.

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Additional data file 5:

Conservation of 118 metabolic pathways analyzed in this study.

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Additional data file 6:

Modularity of 166 metabolic pathways analyzed in this study.

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Additional data file 7:

Conservation of 25 regulatory pathways defined by KEGG.

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