Differential miR-17-92 expression in neuroblastoma tumor samples. Average fold change expression difference of eight different miRNAs residing within the miR-17-92 cluster in MYCN amplified neuroblastoma samples compared to MYCN single copy neuroblastoma samples. Fold changes were calculated upon stable small RNA control (RNU24, RNU44, RNU58A and RNU6B) normalization (dark grey), mean expression value normalization (light grey) and normalization with miRNAs that resemble the mean expression value (miR-425, miR-191 and miR-125a; medium grey.
Mestdagh et al. Genome Biology 2009 10:R64 doi:10.1186/gb-2009-10-6-r64