Additional data file 4.
ChIP-chip results of the miR-17-92 cluster are given for Kelly, IMR5, and WAC2. Oligonucleotide position is given as bars according to the chromosomal localization. Color coding of the bars represents the log2 ratios MYCN versus input from ChIP-chip experiments, were red means positive and green negative values. Histone marks for active transcription (H3K4me3), repression (H3K27me3) and enlongation (H3K36me3) as measured by ChIP-chip are given together with MYCN binding using the same color coding. miRNA transcript information (miRBase version 11.0), CpG islands, and conservation among 28 species were implemented for the region as given by the respective annotation tracks deposited in the UCSC database (Hg 18, release March 2006). Position of canonical (CACGTG) and non-canonical E-boxes from in silico scanning of the respective sequence is given. Grey coding for results of the positional weight matrix (PWM) scan represents the P-values of the 12 bp MYCN binding motif from the TRANSFAC database. Red line = median log2 ratio MYCN versus input as calculated for each chromosome individually.
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Mestdagh et al. Genome Biology 2009 10:R64 doi:10.1186/gb-2009-10-6-r64