Research
A transcriptional network associated with natural variation in Drosophila aggressive behavior
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* Corresponding author: Trudy FC Mackay trudy_mackay@ncsu.edu
1 Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
2 WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
3 Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695, USA
4 Current address: Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Department of Psychiatry, Richmond, VA 23298-0126, USA
Genome Biology 2009, 10:R76 doi:10.1186/gb-2009-10-7-r76
Published: 16 July 2009Additional files
Additional data file 1:
Mean expression level, among (σL2) and within (σE2) line variance components, broad sense heritabilities (H2) and the false discovery rate (FDR) for the line term are for males only.
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Additional data file 2:
The P-value is from the ANOVA of the difference in trait means between the two SFP classes. a is one half the difference in trait mean between the SFP alleles. MAF = minor allele frequency; MAS = mean aggression score.
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Additional data file 3:
Level 3 (a) biological process and (b) molecular function Gene Ontology categories of genes for which variation in gene expression is correlated with variation in aggressive behavior. The percentage of genes falling into a given category is depicted on the x-axis. The relevant genomic background is the 7,508 probe sets that were differentially expressed in males at a FDR of < 0.01. No categories were significantly over-represented among level 3 categories; however, the level 4 'transport' biological process category was over-represented (adjusted P = 0.0364, data not shown).
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Additional data file 4:
(a) Level 3 biological process and (b) level 4 molecular function categories. Only categories applying to at least 5% of a list are depicted. Categories significantly over-represented in the SFP list relative to the genomic background are denoted as follows: *adjusted P < 0.05; **P < 0.01; ***P < 0.001.
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Additional data file 5:
Categories in (a) are level 3 biological processes; those in (b) are level 3 molecular functions. The percent of genes falling into a given category is depicted on the y-axis.
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Additional data file 6:
Average |r| is the mean absolute value of the correlation of the transcript to all other variable transcripts. H2 = broad sense heritability. QTT = quantitative trait transcript; SFP = single feature polymorphism.
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Additional data file 7:
Degree = the average correlation of a transcript with all other transcripts in its module. Average degree = the average correlation of all transcripts in the module.
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Additional data file 8:
Expression of these genes has been correlated with aggressive behavior and the other traits listed. (a) Reference [21]; (b) reference [37].
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