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Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine

Katharine J Webb12*, William HJ Norton12, Dietrich Trümbach3, Annemarie H Meijer4, Jovica Ninkovic126, Stefanie Topp12, Daniel Heck5, Carsten Marr5, Wolfgang Wurst3, Fabian J Theis5, Herman P Spaink4 and Laure Bally-Cuif12*

Author Affiliations

1 Department Zebrafish Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse, Neuherberg, 85764 Germany

2 Center for Integrated Protein Science (Munich), Institute of Developmental Genetics, Technical University - Munich, Ingolstaedter Landstrasse, Neuherberg, 85764 Germany

3 Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse, Neuherberg, 85764 Germany

4 Institute of Biology, University of Leiden, Leiden, 2300 RA The Netherlands

5 Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstrasse, Neuherberg, 85764 Germany

6 Current address: Institute of Stem Cell Research, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse, Neuherberg, 85764 Germany

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Genome Biology 2009, 10:R81  doi:10.1186/gb-2009-10-7-r81

Published: 31 July 2009

Additional files

Additional data file 1:

Complete Unigene list of genes recovered in microarray experiment 1 'wt+/wt-'.

Format: CSV Size: 4.1MB Download file

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Additional data file 2:

Complete Unigene list of genes recovered in microarray experiment 2 'mut+/sib+'.

Format: CSV Size: 4.1MB Download file

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Additional data file 3:

Complete Unigene list of genes recovered in microarray experiment 3 'mut-/sib-'.

Format: CSV Size: 4.1MB Download file

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Additional data file 4:

The 139 genes contained in the reward pool.

Format: XLS Size: 53KB Download file

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Additional data file 5:

Enriched GO terms in individual experiments.

Format: XLS Size: 44KB Download file

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Additional data file 6:

Expression in the adult telencephalon for ten transcripts chosen for validation.

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Additional data file 7:

qPCR data for validated transcripts in conditions of chronic and acute amphetamine administration.

Format: XLS Size: 32KB Download file

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Additional data file 8:

Expression of her15, gfi1b, foxg1 and lhx8 in the adult brain upon amphetamine administration.

Format: PDF Size: 4.9MB Download file

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Additional data file 9:

Primers and probes used for qPCR.

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Additional data file 10:

Primers used to clone in situ hybridization probes.

Format: PPT Size: 39KB Download file

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