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Virus-mediated mRNA decay by hyperadenylation

Kevin J Sokoloski, Emily L Chaskey and Jeffrey Wilusz*

Author Affiliations

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA

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Genome Biology 2009, 10:234  doi:10.1186/gb-2009-10-8-234

Published: 11 August 2009

Abstract

Degradation of cellular mRNAs during Kaposi's sarcoma-associated herpesvirus infection is associated with hyperadenylation of transcripts and a relocalization of cytoplasmic poly(A)-binding proteins to the nucleus.