Schematic representation of the claudin monomer. The model depicts the conserved structural features of claudins and some of the known interactions and modifications. EL1 and EL2 denote the extracellular loops 1 and 2, respectively. The transmembrane domains 1 to 4 (TM1 to TM4) and the regions important for hepatitis C virus (HCV) entry and Clostridium perfringens enterotoxin (CPE) binding are shown.
Lal-Nag and Morin Genome Biology 2009 10:235 doi:10.1186/gb-2009-10-8-235