Table 2

Human claudin genes and transcript information

Gene

Localization

Introns

Transcript information

Protein size

Molecular weight

Pi


CLDN1

3q28

3

One form

211

22,744

8.41

CLDN2

Xq22

1

One form

230

24,549

8.47

CLDN3

7q11

0

One form

220

23,319

8.37

CLDN4

7q11

0

One form

209

22,077

8.38

CLDN5

22q11

1

Two variants: alternative splicing, coding unaffected

218

23,147

8.25

CLDN6

16p13

1

One form

220

23,292

8.32

CLDN7

17p13

3

One form

211

22,390

8.91

CLDN8

21q22

0

One form

225

24,845

9

CLDN9

16p13

1

One form

217

22,848

6.54

CLDN10

13q31

1

Two variants: alternative transcription start site, different amino termini

a: 226

24,251

9.24

b: 228

24,488

8.32

CLDN11

3q26

2

One form

207

21,993

8.22

CLDN12

7q21

2

One form

244

27,110

8.8

CLDN14

21q22

2

Two variants: alternative splicing, coding unaffected

239

25,699

8.94

CLDN15

7q11

4

One form

228

24,356

5.61

CLDN16

3q28

4

One form

305

33,836

8.26

CLDN17

21q22

0

One form

224

24,603

9.8

CLDN18

3q34

4

Two variants: alternative transcription start site, different amino termini

a: 261

27,856

8.39

b: 261

27,720

8.39

CLDN19

1p34

4

Two variants: alternative splicing, different carboxyl termini

a: 224

23,229

8.48

b: 211

22,076

7.52

CLDN20

6q25

1

One form

219

23,515

6.98

CLDN21

11q23

0

One form

229

25,393

5.37

CLDN22

4q35

0

One form

220

25,509

5.37

CLDN23

8p23

0

One form

292

31,915

7.51

CLDN24

4q35

0

One form

205

22,802

4.87


The chromosomal localization, intron number, and transcript details are indicated for each of the claudin genes, together with the size (in amino acids), molecular weight (in Da), and isoelectric point (Pi) of their encoded proteins. CLDN10, CLDN18, and CLDN19 have two variants giving rise to slightly different proteins. Only the variants documented in GenBank are indicated and other variants may exist.

Lal-Nag and Morin Genome Biology 2009 10:235   doi:10.1186/gb-2009-10-8-235