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Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes

Xianjun Dong12, David Fredman13 and Boris Lenhard12*

Author affiliations

1 Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway

2 Sars Centre for Marine Molecular Biology, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway

3 Current address: Department for Molecular Evolution and Development, Centre for Organismal Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse, 1090 Wien, Austria

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Citation and License

Genome Biology 2009, 10:R86  doi:10.1186/gb-2009-10-8-r86

Published: 21 August 2009

Abstract

Genomic regulatory blocks are chromosomal regions spanned by long clusters of highly conserved noncoding elements devoted to long-range regulation of developmental genes, often immobilizing other, unrelated genes into long-lasting syntenic arrangements. Synorth http://synorth.genereg.net/ webcite is a web resource for exploring and categorizing the syntenic relationships in genomic regulatory blocks across multiple genomes, tracing their evolutionary fate after teleost whole genome duplication at the level of genomic regulatory block loci, individual genes, and their phylogenetic context.