Figure 3.

Identification of a gene cluster associated with the silencing of TIA proteins. (a) Venn diagrams depicting the numbers of genes that were up-regulated (left) or down-regulated (right) by TIA-1 (green), TIAR (red) or TIA-1 plus TIAR (blue) silencing. All data for all genes are presented in Additional data files 2 to 5 and 7 and 8. (b) Gene cluster defining a molecular signature of up- (highlighted in red) and down-regulated (highlighted in green) genes in TIA-1 and TIAR-depleted HeLa cells. The microarray data were analyzed by the Rank Products method [29]. Fold is an average measure of the fold change in differential expression and the false discovery rate (FDR) indicates the expected percentage of false positives. The Probe-set ID is the Unigene probe-set identifier [43].