Figure 7.

Interaction network associated with the gene cluster induced upon suppression of TIA proteins. Visualization of biochemical relationships between gene clusters up-regulated (red) and down-regulated (green) identified by microarray analyses were computed using the Pathway Studio (version 6.0) software and the 'ResNet Mammalian' database developed by Ariadne Genomics, Inc. [40]. The network topology illustrates positive (red boxes) and negative (green boxes)-regulated cell processes based on interactions after inactivation of TIA proteins. The nature of the regulators is depicted schematically as shown in the legend to the right. Continuous and dotted lines illustrate direct and indirect protein-protein interactions, respectively. The thickness of blue lines is proportional to the number of interactions reported in the literature.