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Common variants in polygenic schizophrenia

Joseph T Glessner1 and Hakon Hakonarson2*

Author Affiliations

1 Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA

2 Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA

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Genome Biology 2009, 10:236  doi:10.1186/gb-2009-10-9-236

Published: 29 September 2009

Abstract

Common variant single-nucleotide polymorphisms at the MHC locus have recently been associated with schizophrenia. Together with known associations with rare copy-number variants affecting many genes, this reveals the highly polygenic etiology of the disease.