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Predicting drug side-effects by chemical systems biology

Nicholas P Tatonetti1, Tianyun Liu2 and Russ B Altman23*

Author Affiliations

1 Training Program in Biomedical Informatics, Stanford University, Stanford, CA 94305, USA

2 Department of Bioengineering, Stanford University, Stanford, CA 94305, USA

3 Department of Genetics, Stanford University, Stanford, CA 94305, USA

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Genome Biology 2009, 10:238  doi:10.1186/gb-2009-10-9-238

Published: 2 September 2009

Abstract

New approaches to predicting ligand similarity and protein interactions can explain unexpected observations of drug inefficacy or side-effects.