FLN shows improvement over PPI network for predicting 'new' disease genes. Disease genes whose disease-association landmark references were published before January 2007 are considered 'known' and are used as seed genes, and disease genes that were published after January 2007 are considered 'new' and are used as test genes. Performances are compared among FLN, PPI network, and the random control of the FLN. Gene-centric assessment is used to evaluate the performance using the artificial chromosome region background composed of 100 genes, as described in the legend of Figure 4b.
Linghu et al. Genome Biology 2009 10:R91 doi:10.1186/gb-2009-10-9-r91