Figure 1.

Nuclear pet genes of S. cerevisiae. (a) The numbers of pet mutants identified in three screens of the yeast deletion library are indicated. References: Dimmer et al. [14], Luban et al. [17]. (b) The intracellular location of proteins encoded by pet genes has been grouped according to their frequency of occurrence in screens of the deletion library. The graph is a summary of data contained in Additional data file 3. (c) Cellular functions of proteins encoded by highly penetrant pet genes. Functions have been assigned according to data from the Saccharomyces Genome Database [19] and manual annotation. Red indicates mitochondrial proteins, green known extra-mitochondrial proteins, grey unknown proteins, and white dubious ORFs overlapping with known protein-coding genes.