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Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts

Ishita S Mehta, Manelle Amira, Amanda J Harvey and Joanna M Bridger*

Genome Biology 2010, 11:R5 doi:10.1186/gb-2010-11-1-r5

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Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells

Ishita S Mehta, Christopher H Eskiw, Halime D Arican, Ian R Kill, Joanna M Bridger Genome Biology 2011, 12:R74 (12 August 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Treating cultured cells from Hutchinson-Gilford progeria patients with farnesyltransferase inhibitors restores wildtype chromosome dynamics

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The yin and yang of chromatin spatial organization

Nathan F Cope, Peter Fraser, Christopher H Eskiw Genome Biology 2010, 11:204 (29 March 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Chromatin interactions, both in cis and trans and between transcriptionally active and silent regions, mean that the spatial organization of the genome is non-random.

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