Figure 5.

BDNF mRNA level normalized to EAR in the human post-mortem cortex (a) Application of the GeNorm algorithm to six genes to identify the three most stable housekeeping genes in human post-mortem cortex. Average expression stability values (M) of remaining control genes during stepwise exclusion of the least stable control gene in the human cortex of seven control participants. (b) BDNF mRNA levels in the human cortex of seven control participants and seven HD patients normalized to GAPDH (Zuccato et al. [8]) and EAR mRNA.