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Highly Accessed Review

Capturing the dynamic epigenome

Roger B Deal1 and Steven Henikoff12*

Author Affiliations

1 Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

2 Howard Hughes Medical Institute, Seattle, WA 98109, USA

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Genome Biology 2010, 11:218 doi:10.1186/gb-2010-11-10-218

Published: 8 October 2010

Abstract

Traditional methods for epigenomic analysis provide a static picture of chromatin, which is actually a highly dynamic assemblage. Recent approaches have allowed direct measurements of chromatin dynamics, providing deeper insights into processes such as transcription, DNA replication and epigenetic inheritance.