Strain divergence in CDC-transcriptome coexpression within and between CDC-phase groups. (a) Heat map of Mantel matrix correlation coefficients between pairs of strains for each of three CDC-phase groups (Early: E, Middle: M, Late: L), corresponding to the first, middle, and last nine sampled timepoints. Correlations were computed between pairs of 6,082 × 6,082 genome-wide CDC-expression correlation matrices. (b) Hierarchical clustering of the correlation matrix shown in (a). (c) Hierarchical clusterings for data within each CDC-phase group, corresponding to the three main diagonal blocks (outlined in (a)). Clustering was performed using average linkage with the Pearson correlation metric.
Simola et al. Genome Biology 2010 11:R105 doi:10.1186/gb-2010-11-10-r105