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Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

Claudio Donati1*, N Luisa Hiller2, Hervé Tettelin3, Alessandro Muzzi1, Nicholas J Croucher4, Samuel V Angiuoli3, Marco Oggioni5, Julie C Dunning Hotopp3, Fen Z Hu2, David R Riley3, Antonello Covacci1, Tim J Mitchell6, Stephen D Bentley4, Morgens Kilian7, Garth D Ehrlich2, Rino Rappuoli1, E Richard Moxon8 and Vega Masignani1

Author Affiliations

1 Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy

2 Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania 152123, USA

3 Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, 801 West Baltimore Street, MD 21201, USA

4 The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

5 Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita' di Siena, Policlinico Le Scotte, 53100 Siena, Italy

6 Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK

7 Institute of Medical Microbiology and Immunology, Aarhus University, DK-8000 Aarhus, Denmark

8 University of Oxford Department of Paediatrics, Medical Sciences Division, John Radcliffe Hospital, Headington OX3 9DU, UK

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Genome Biology 2010, 11:R107  doi:10.1186/gb-2010-11-10-r107

Published: 29 October 2010

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