The S. pneumoniae pan-genome according to the finite supragenome model. (a) Number of new genes as a function of the number of sequenced genomes. The predicted number of new genes drops sharply to zero when the number of genomes exceeds 50. (b) Number of core genes as a function of the number of sequenced genomes. The number of core genes converges to 1,647 for number of genomes n→∞.
Donati et al. Genome Biology 2010 11:R107 doi:10.1186/gb-2010-11-10-r107