Figure 1.

Sample inheritance vector output from Hapi imported into a spreadsheet. Output from Hapi showing the inherited homologs on chromosome 1 for a family with 11 children from the Huntington's Disease Venezuela Collaborative Study [32]. Hapi produces CSV format output, which we imported into a spreadsheet. To color the cells, we used conditional formatting based on the homolog value transmitted. The output of inheritance vector values uses letters A and B. Lower-case letters indicate the transmitting parent is homozygous and the presence of recombination unknown. Each column is labeled with the child's numerical id with either a 'P' or an 'M' preceding it to indicate either paternal or maternal-derived homologs. The left most column gives the SNP rs numbers, and the right most column lists the number of recombinations across all children at the given locus.