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Highly Accessed Opinion

Contribution of histone sequence preferences to nucleosome organization: proposed definitions and methodology

Noam Kaplan1, Timothy R Hughes2,3, Jason D Lieb4, Jonathan Widom5* and Eran Segal1,6*

Author Affiliations

1 Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel

2 Terrence Donnelly Centre for Cellular and Biomolecular Research, 160 College Street, Toronto, Ontario M5 S 3E1, Canada

3 Banting and Best Department of Medical Research, 112 College St, Toronto, Ontario M5 S 1L6, Canada

4 Department of Biology and the Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

5 Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2153 Sheridan Road, Evanston, IL 60208, USA

6 Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel

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Genome Biology 2010, 11:140 doi:10.1186/gb-2010-11-11-140

Published: 30 November 2010

Abstract

We propose definitions and procedures for comparing nucleosome maps and discuss current agreement and disagreement on the effect of histone sequence preferences on nucleosome organization in vivo.