Table 2

Top categories of general molecular types

General molecular function

Number of genes

Examples


LOH genes

Enzyme

80

USP26, INPP5K, PTPRS, MAT2B

Kinase

25

CDK7, DGKE, MAP2K4, PDGFRL

Transporter

21

ATP2B3, SLC36A3, SIL1, ABCA7

Transcription regulator

20

BRCA1, FOXD4, SOX5, VEZF1

G-protein coupled receptor

19

GPR174, OR1A2, TAS2R7, GRM6

Transmembrane receptor

9

SEMA5A, IL31RA, ITGB3, OSMR

Cytokine

7

IL3, ERBB2IP, EDA, CXCL16

Ion channel

6

CCT8L2, CNGA2, GABRA6, GRIN3B

ASE genes

Enzyme

18

MGMT, PLCH1, GUCY1A3, PYGL

Transcription regulator

7

CTBP2, SMARCA4, BCLAF1, SPEN

Kinase

6

FGFR2, FGFR4, IP6K2, TAOK1

Transporter

5

SLC44A5, SLC25A5, SNX15, LBP

Transmembrane receptor

3

HLA-DQA1, HLA-A, TNFRSF10D

G-protein coupled receptor

2

ADORA1, GPR107


Genes are binned exclusively into each category based on their primary molecular function terms. LOH, loss of heterozygosity; ASE, allele-specific expression.

Zhao et al. Genome Biology 2010 11:R114   doi:10.1186/gb-2010-11-11-r114

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