Table 4

Selected list of LOH or ASE genes: known or putative tumor suppressor genes

Gene product and functional properties

Reported functional studies in cancer


LOH genes

BRCA1

Breast cancer 1, a nuclear phosphoprotein involved in maintaining DNA stability

Tumor suppressor function [43]

MSH3

MutS homolog 3, a subunit of MutS beta involved in DNA mismatch repair

Genetic instability caused by loss of MSH3 in cancers [44]

PCGF2

Polycomb group ring finger 2, involved in protein-protein interaction and transcription repression

Tumor suppressor function [45]

PDGFRL

Platelet-derived growth factor receptor-like, a cell surface tyrosine kinase receptor

Mutation and gene loss correlated with breast cancer progression [46] and prostate cancer [47]

BCR

Breakpoint cluster region

Putative tumor suppressor in meningiomas [48]

ASE genes

DSC3

Desmocollin 3, a cell adhesion molecule in cadherin family

Epigenetic silencing of DSC3 is a common event in breast cancer [49]

FGFR2

Fibroblast growth factor receptor 2, a transmembrane tyrosine kinase

Hypermethylation of FGFR2 found in gastric cancer [50]

MYEOV

Myeloma overexpressed, a putative transforming gene

Epigenetically inactivated in esophageal squamous cell carcinomas [51]

TNFRSF10D

Tumor necrosis factor receptor superfamily, member 10 d, a member of TNF-receptor superfamily

Aberrant methylation in multiple tumor type and mapped to tumor suppressor region in prostate cancer [52,53]

MGMT

O-6-methylguanine-DNA methyltransferase, a DNA repair gene

Methylation of MGMT in many types of cancers [41,42,54] and associated with poorer overall and disease-free survival [55]


LOH, loss of heterozygosity; ASE, allele-specific expression.

Zhao et al. Genome Biology 2010 11:R114   doi:10.1186/gb-2010-11-11-r114

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