Association with BMI. (a) Significance of the association with BMI identified by single marker tests (-log10(chi-square P-value)) for all SNVs located in the MGLL interval (x-axis, NCBI36 coordinates). SNPs with a P-value < 0.01 are highlighted in red. The recombination rate  in the HapMap CEU population for this region is indicated by a blue line and measured on the right axis. (b,c) Significance of the association with BMI for all locus-variants identified by RareCover (see Materials and methods) in the MGLL (a) and FAAH (b) sequenced intervals. For both genes, locus-variants with a P-value < 0.01 are highlighted in red. The MGLL and FAAH gene structures are aligned based on their genomic positions.
Harismendy et al. Genome Biology 2010 11:R118 doi:10.1186/gb-2010-11-11-r118