Software
The Genomic HyperBrowser: inferential genomics at the sequence level
1 Department of Informatics, University of Oslo, Blindern, 0316 Oslo, Norway
2 Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
3 Statistics For Innovation, Norwegian Computing Center, 0314 Oslo, Norway
4 Department of Mathematics, University of Oslo, Blindern, 0316 Oslo, Norway
5 Centre for Cancer Biomedicine, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
6 Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
7 Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Blindern, 0317 Oslo, Norway
Genome Biology 2010, 11:R121 doi:10.1186/gb-2010-11-12-r121
Published: 23 December 2010Abstract
The immense increase in the generation of genomic scale data poses an unmet analytical challenge, due to a lack of established methodology with the required flexibility and power. We propose a first principled approach to statistical analysis of sequence-level genomic information. We provide a growing collection of generic biological investigations that query pairwise relations between tracks, represented as mathematical objects, along the genome. The Genomic HyperBrowser implements the approach and is available at http://hyperbrowser.uio.no webcite.
