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Novel genes exhibit distinct patterns of function acquisition and network integration

John A Capra12, Katherine S Pollard1* and Mona Singh2*

Author affiliations

1 Gladstone Institutes, University of California, San Francisco, 1650 Owens St, San Francisco, CA 94158, USA

2 Department of Computer Science and Lewis-Sigler Institute for Integrative Genomics, Princeton University, 35 Olden St, Princeton, NJ 08544, USA

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Citation and License

Genome Biology 2010, 11:R127  doi:10.1186/gb-2010-11-12-r127

Published: 27 December 2010

Abstract

Background

Genes are created by a variety of evolutionary processes, some of which generate duplicate copies of an entire gene, while others rearrange pre-existing genetic elements or co-opt previously non-coding sequence to create genes with 'novel' sequences. These novel genes are thought to contribute to distinct phenotypes that distinguish organisms. The creation, evolution, and function of duplicated genes are well-studied; however, the genesis and early evolution of novel genes are not well-characterized. We developed a computational approach to investigate these issues by integrating genome-wide comparative phylogenetic analysis with functional and interaction data derived from small-scale and high-throughput experiments.

Results

We examine the function and evolution of new genes in the yeast Saccharomyces cerevisiae. We observed significant differences in the functional attributes and interactions of genes created at different times and by different mechanisms. Novel genes are initially less integrated into cellular networks than duplicate genes, but they appear to gain functions and interactions more quickly than duplicates. Recently created duplicated genes show evidence of adapting existing functions to environmental changes, while young novel genes do not exhibit enrichment for any particular functions. Finally, we found a significant preference for genes to interact with other genes of similar age and origin.

Conclusions

Our results suggest a strong relationship between how and when genes are created and the roles they play in the cell. Overall, genes tend to become more integrated into the functional networks of the cell with time, but the dynamics of this process differ significantly between duplicate and novel genes.