Subnetwork of the yeast protein physical interaction network consisting of young novel proteins and their first-degree neighbors. Young novel proteins are shown in red; young duplicate proteins are colored blue; and all others are gray. Nearly half of all young novel proteins are found in a single connected component (top of figure). The network module highlighted by the orange box consists of two young novel proteins interacting with a number of proteins involved in actin formation and processing. The protein highlighted in green is notable because it interacts or is within one neighbor of seven young novel proteins. Its function and those of nearby proteins suggest a role in membrane trafficking for several of the young novel proteins. Note that interacting protein pairs with no other interactions in this subnetwork are not listed. This visualization is based on the circular layout in CytoScape .
Capra et al. Genome Biology 2010 11:R127 doi:10.1186/gb-2010-11-12-r127