Table 3 |
||
|
Assigning putative functions to longevity genes |
||
|
Gene |
Gene Ontology biological process |
P-value |
|
|
||
|
rpl-4 |
Cellular macromolecular complex assembly |
2.16E-02 |
|
vit-5 |
Phosphate transport |
3.70E-05 |
|
rha-2 |
Cellular macromolecular complex assembly |
2.16E-02 |
|
C06E7.1 |
Protein complex assembly |
2.26E-02 |
|
C25H3.6* |
Transcription from RNA polymerase II promoter |
4.87E-02 |
|
pat-4 |
Chromatin assembly or disassembly |
4.92E-03 |
|
C33H5.18 |
Chromatin assembly or disassembly |
3.02E-03 |
|
unc-60 |
Protein complex assembly |
2.26E-02 |
|
vit-2 |
Phosphate transport |
3.70E-05 |
|
ril-1* |
Cell adhesion |
3.57E-02 |
|
CD4.4* |
Ribosome biogenesis |
1.85E-02 |
|
eif-3.F |
Organelle organization and biogenesis |
3.75E-03 |
|
F09F7.5* |
Pigment metabolic process |
5.01E-03 |
|
pab-2 |
Chromatin assembly or disassembly |
8.99E-05 |
|
hpk-1 |
Growth |
2.78E-02 |
|
mdh-1 |
Lipid metabolic process |
3.36E-02 |
|
blmp-1 |
Chromatin assembly |
7.22E-04 |
|
daf-3 |
Protein complex assembly |
2.26E-02 |
|
F28B3.5* |
Amine metabolic process |
3.04E-03 |
|
rps-23 |
tRNA aminoacylation for protein translation |
1.04E-03 |
|
F30A10.10 |
Chromatin assembly or disassembly |
4.95E-02 |
|
dlk-1 |
Transcription from RNA polymerase II promoter |
4.87E-02 |
|
F40F8.5* |
Nucleobase metabolic process |
5.08E-05 |
|
elo-5 |
Lipid metabolic process |
4.34E-02 |
|
F43G9.3 |
Water-soluble vitamin metabolic process |
2.04E-03 |
|
ife-1 |
Organelle organization and biogenesis |
3.75E-03 |
|
spt-4 |
Chromatin assembly or disassembly |
8.40E-05 |
|
aakb-1 |
Nucleobase, nucleoside and nucleotide metabolic process |
1.45E-03 |
|
dod-22* |
Gene expression |
1.85E-02 |
|
F57B9.3 |
Amine metabolic process |
2.83E-02 |
|
cdc-25.1 |
Amine metabolic process |
1.90E-02 |
|
nac-3 |
Cellular macromolecular complex assembly |
2.16E-02 |
|
lin-23 |
Cytoskeleton organization and biogenesis |
2.59E-02 |
|
K10D2.2 |
Anion transport |
5.54E-04 |
|
ifg-1 |
Organelle organization and biogenesis |
3.75E-03 |
|
sir-2.1 |
Lipid transport |
2.44E-04 |
|
wip-1* |
Chromatin assembly or disassembly |
1.99E-02 |
|
skn-1 |
Chromatin assembly or disassembly |
3.56E-04 |
|
vha-6 |
Regulation of metabolic process |
3.84E-02 |
|
W01B11.3 |
Establishment of protein localization |
1.93E-04 |
|
W06B11.3* |
Fatty acid metabolic process |
6.78E-03 |
|
rpl-30 |
Chromatin assembly or disassembly |
3.02E-03 |
|
tag-300 |
Cytoskeleton organization and biogenesis |
2.59E-02 |
|
Y42G9A.4 |
Chromatin assembly or disassembly |
3.32E-02 |
|
gdi-1 |
Secondary metabolic process |
1.98E-02 |
|
spl-1 |
Sulfur metabolic process |
2.33E-02 |
|
pod-1 |
Intracellular protein transport |
2.04E-02 |
|
lrs-2 |
Intracellular protein transport |
2.04E-02 |
|
let-60 |
Nucleotide-excision repair |
1.11E-02 |
|
|
||
|
The first column lists longevity genes, column 2 shows the most highly enriched Gene Ontology biological process in subnetworks containing that gene, and the P-value of the enrichment (hypergeometric test with FDR correction) is shown in column 3. Genes with no previously known manual Gene Ontology biological process annotation are indicated with an asterisk. |
||
|
Fortney et al. Genome Biology 2010 11:R13 doi:10.1186/gb-2010-11-2-r13 |
||
