Additional file 10.

Base substitution distributions in hSNPs were used a background nucleotide substitution rates in calculating an expected distribution of ESE/ESS changes of the NI-ESR hexamer set (Figure 3). Significant differences in distributions between skipping SAVs and hSNPs (such as that seen in A->T, T->C and G->T) and ectopic SAVs (A->T, A->C, T->A, C->G) while potentially of biological interest, should be treated with caution due to small number of skipping and ectopic SAVs and large discrepancy in dataset size between these sets and HapMap SNPs.

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Woolfe et al. Genome Biology 2010 11:R20   doi:10.1186/gb-2010-11-2-r20