Table 4

Pathways from the small cell lung cancer dataset found exclusively by PWEA

Pathway

Size

DE fraction^a

Type

Possible relation to the cancer

Reference

GnRH signaling pathway

78

37%

Endocrine system

Negative autocrine regulator

[43,79]

Complement and coagulation cascades

56

54%

Immune system

Inflammation

Metastatic and invasive properties

[80]

MAPK signaling pathway

199

38%

Signal transduction

Cell growth

-

Fc epsilon RI signaling pathway

63

44%

Immune system

Angiogenesis

Inflammation

[37,41,42]

Apoptosis

67

34%

Cell growth and death

Apoptosis

-

ABC transporters

34

24%

Membrane transport

Drug resistance

[81]

Jak-STAT signaling pathway

93

37%

Signal transduction

Cell growth

[47-49]

Drug metabolism - cytochrome P450

41

51%

Xenobiotics biodegradation and metabolism

Anticancer drugs topotecan and etoposide

[75]

Drug metabolism - other enzymes

28

46%

Xenobiotics biodegradation and metabolism

Anticancer drug irinotecan

[75]

Histidine metabolism

24

42%

Amino acid metabolism

Nutrition intake.

Small cell lung cancer marker, DDC involved.

[82,83]

Tryptophan metabolism

36

39%

Amino acid metabolism

As above

[82,83]

Phenylalanine metabolism

13

54%

Amino acid metabolism

As above

[82,83]

Fatty acid metabolism

37

38%

Lipid metabolism

Apoptosis.

Therapeutic target

[84,85]

Basal cell carcinoma

36

17%

Disease

Proliferation invasion through hedgehog signaling pathway

-

^aDE fraction is the fraction of genes that show differential expression with P < 0.05 using a two-tailed t-test. DDC: enzymatic neuroendocrine markers L-DOPA decarboxylase.

Hung et al. Genome Biology 2010 11:R23   doi:10.1186/gb-2010-11-2-r23