Figure 2.

Hsp90 functions in the suppression of transposon-mediated 'canonical' mutagenesis via the piRNA pathway. (a) Activated transposons can move from one site in a genome to another by the process of transposition and so have the potential to induce de novo gene mutations by insertion. Hsp90 could be involved in the control of transposition by affecting piRNA biogenesis. (b) Reduced Hsp90 function leads to transposon-mediated insertional mutagenesis and the induction of morphological variability, such as variation in eye and body color.