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Genome-wide DNA demethylation in mammals

Lionel A Sanz, Satya K Kota and Robert Feil*

Author Affiliations

Institute of Molecular Genetics, CNRS UMR-5535 and University of Montpellier, 1919 route de Mende, 34293 Montpellier, France

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Genome Biology 2010, 11:110 doi:10.1186/gb-2010-11-3-110

Published: 16 March 2010

Abstract

The cytidine deaminase AID and elongator-complex proteins contribute to the extensive removal of DNA methylation in mammalian primordial germ cells and in the paternal pronucleus of the zygote.