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Highly Accessed Review

The yin and yang of chromatin spatial organization

Nathan F Cope, Peter Fraser and Christopher H Eskiw*

Author Affiliations

Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK

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Genome Biology 2010, 11:204 doi:10.1186/gb-2010-11-3-204

Published: 29 March 2010

Abstract

Spatial organization of the genome is non-random. Preferential chromatin interactions, both in cis and in trans and between transcriptionally active and silent regions, influence organization.