False discovery plots comparing several published methods. The red line depicts the length-normalized moderated t-statistic analysis. The solid and dashed lines show the library size normalized and TMM normalized Poisson model analysis, respectively. The blue and black lines represent the LR test and exact test, respectively. It can be seen that the use of TMM normalization results in a much lower false discovery rate.
Robinson and Oshlack Genome Biology 2010 11:R25 doi:10.1186/gb-2010-11-3-r25