Figure 5.

Characterization of an 8-nucleotide DNA motif in the 5'UTR of human NRTKs. (a) Representative motif and its reverse complement. (b) Comparison of the representative motif to the TRANSFAC v11.3 database of known transcription factor binding sites. (c) Comparison of the representative motif to a list of conserved human predicted motifs [46]. STAMP website was used for the comparisons [47]. The default ungapped Smith-Waterman alignment was used and the P-value was calculated using the methods of Sandelin and Wasserman [74].